Open the history,.;.;''//// https://www.highcpmgate.com/i9wxe52s77?key=797d33e3786455ffce63699420e0bd3c Koch's postulates ( / k ɒ x / KOKH ) [2] are four criteria designed to establish a causal relationship between a microbe and a disease . The postulates were formulated by Robert Koch and Friedrich Loeffler in 1884, based on earlier concepts described by Jakob Henle , and the statements were refined and published by Koch in 1890. [3] Koch applied the postulates to describe the etiology of cholera and tuberculosis , both of which are now ascribed to bacteria . The postulates have been controversially generalized to other diseases. More modern concepts in microbial pathogenesis cannot be examined using Koch's postulates, including viruses (which are obligate intracellular parasites ) and asymptomatic carriers . They have large...
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